Busulfan in combination with cyclophosphamide or melphalan: Adverse reactions reported both in adults and paediatric patients as more than an isolated case are listed as follows, by system organ class and by frequency. Within each frequency grouping, adverse events are presented in order of decreasing seriousness. (See Table 2.)
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Busulfan in combination with fludarabine (FB): The incidence of each adverse reactions presented in the following table has been defined according to the highest incidence observed in published clinical trials in RIC regimen for which the population treated with FB was clearly identified, whatever the schedules of busulfan administrations and endpoints. Adverse reactions reported as more than an isolated case are listed as follows, by system organ class and by frequency. (See Table 3.)
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
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