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Drugs That May Increase Cabazitaxel Plasma Concentrations: CYP3A4 Inhibitors: Cabazitaxel is primarily metabolized through CYP3A. Concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole) is expected to increase concentrations of cabazitaxel. Therefore, co-administration with strong CVYP3A inhibitors should be avoided. Caution should be exercised with concomitant use of moderate CYP3A inhibitors.
Drugs That May Decrease Cabazitaxel Plasma Concentrations: CYP3A4 Inducers: Concomitant administration of strong CYP3A inducers (e.g., phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital) is expected to decrease cabazitaxel concentrations. Therefore, co-administration with strong CYP3A inducers should be avoided.
