Caraten Dosage/Direction for Use

Recommended Dose: Hypertension: an initial oral dose is 12.5 mg once daily increased after two days to 25 mg once daily. Alternatively, an initial dose of 6.25 mg is given twice daily, increased after one or two weeks to 12.5 mg twice daily. The dose may be increased further, if necessary, at intervals of at least two weeks to 50 mg once daily or in divided doses (twice daily). A dose of 12.5 mg once daily maybe adequate in elderly patients.
Angina pectoris: an initial dose is 12.5 mg orally twice daily, increased after two days to 25 mg twice daily.
Impaired left ventricular function following myocardial infarction: the initial dose is 6.25 mg orally twice daily; increased after 3 to 10 days, if tolerated, to 12.5 mg twice daily and then to a target dose of 25 mg twice daily. A lower initial dose may be used in symptomatic patients.
Heart failure: the initial dose is 3.125 mg orally twice daily. If tolerated, the dose should be doubled after two weeks to 6.25 mg twice daily and then increased gradually, at intervals of not less than two weeks, to the maximum dose tolerated; this should not exceed 25 mg twice daily in patients with severe heart failure or in those weighing less than 85 kg, or 50 mg twice daily in patients with mild to moderate heart failure weighing more than 85 kg.
If a Dose is Missed: If the patient misses a dose or forgets to use the medicine, use as soon as he/she can. If it is almost time for the next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
Dose Adjustments: Dosage in Renal Failure: carvedilol are excreted less than 1% and dosing adjustments are not required in patients with renal insufficiency.
Dosage Adjustment During Dialysis: Dosing adjustments are not required in chronic hemodialysis patients.
Dosage in Hepatic Insufficiency: Carvedilol is extensively metabolized in the liver and dose reductions are suggested in patients with hepatic insufficiency. Initiated with approximately 20% of the normal dose in patients with liver cirrhosis.
Dosage in Geriatric Patients: elderly subjects may be more susceptible to the postural hypotensive effects of carvedilol, suggesting that lower doses should be considered initially.
Pediatric Dosing: safety and efficacy in children have not been established.
Mode of Administration: Tablets for oral use. Should be taken with food to minimize the risk of orthostatic hypotension.