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Overdose: Little human data. Hypotension, bradycardia and QRS widening have been reported. Hypoglycemia (especially in children and diabetics), decreased mental status and seizures are possible but not yet reported. ADVERSE EFFECTS: Hypotension, orthostatic hypotension, syncope, bradycardia and dizziness can occur.
Treatment: Decontamination: Activated charcoal, gastric lavage.
Hypotensive episode: IV 0.9% NS, dopamine, norepinephrine. If bradycardic administer atropine, glucagon (bolus of 50 to 150 mcg/kg over 1 minute {usually about 10 mg in an adult} then a continuous IV infusion of 1 to 5 mg/hour in D5W).
Hypoglycemia: Intravenous dextrose.
Seizure: Benzodiazepines, barbiturates.
Monitoring of patient: Monitor blood pressure frequently. Institute continuous cardiac monitoring and obtain an ECG. Monitor blood glucose in patients with decreased mental status, children and diabetics.
