Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine; an initial dose of 5 mg once daily, or 10 mg every other day is recommended. Efficacy of Carinose tablet has not been established in children younger than 2 years of age. However, the pharmacokinetic profile of loratadine in children 1 to 2 years of age after the administration of a single 2.5 mg dose of loratadine is similar to that In older children and adults, therefore. use only if the potential benefit justifies the potential risk.
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