Cefper Dosage/Direction for Use

Use in adults: Each vial contains Cefoperazone 500 mg and Sulbactam 500 mg. Daily dosage recommendation in adults is 2 - 4 g (1 - 2 g Cefoperazone activity) by intravenous administration/intramuscular administration.
Dose should be administered every 12 hours in equally divided doses. In severe or refractory infection the daily dosage of Sulbactam/Cefoperazone may be increased up to 8 g (4 g Cefoperazone activity).
Doses should be administered every 12 hours in equally divided doses.
Use in children: Daily dosage recommendation is 40 - 80 mg/kg/day (20 - 40 mg/kg/day Cefoperazone activity) by intravenous administration/intramuscular administration every 6 to 12 hours in equally divided doses. In severe or refractory infections the daily dosage of Sulbactam/Cefoperazone may be increased up to 160 mg/kg/day (80 mg/kg/day Cefoperazone activity). Doses should be administered in two to four equally divided doses.
Intravenous administration: For intermittent infusion. Each vial of Sulbactam/Cefoperazone should be reconstituted with sterile water for injection to obtain 4 ml of solution and then diluted to 20 ml with the same solution followed by administration over 15 to 60 minutes. The reconstituted solution should be kept in room temperature (23 - 29°C ) not more than 24 hours or 2 - 8°C not more than 5 days.
Intramuscular administration: Lidocaine HCl 2% is a suitable vehicle for intramuscular administration, however, not for initial reconstitution.