Dobutel Dosage/Direction for Use

The rate of infusion needed to increase cardiac output usually 2.5-10 μg/Kg/min. On rare occasions, infusion rates up to 40 μg/Kg/min have been required to obtain the desired effect. The dosage should be adjusted individually, according to the patient's heart rate and rhythm, blood pressure and diuresis. Partial tolerance may develop if infusion time exceeds 72 hrs and such cases may call for an increase in dosage.
Infusion concentrate 50 mg/mL (250 mg/5mL): The dosage is determined as follows: See table.

Click on icon to see table/diagram/image

The infusion rate values corresponding to each dosage are multiplied by the patient's weight as kilograms. This gives the infusion rate as mL/min.
Dilution: For infusion, the infusion concentrate is diluted in physiological sodium chloride (0.9% sodium chloride injection), 5% glucose injection, 5% glucose and 0.9% sodium chloride injection, 20% mannitol injection, Ringer's lactate injection, or Ringer's lactate and 5% glucose injection. The prepared infusion solution should be used within 30 hours. (See Storage.)
Note: Do not add Dobutel Injection to Sodium bicarbonate injection or to any other strongly alkaline solution. Because of potential physical incompatibilities, it is recommended that Dobutel injection not be mixed with other drugs in the same solution. Dobutel injection should not be used in conjunction with other agents or diluents containing both sodium bisulfite and ethanol.