In clinical studies, no evidence has been found of drug interactions between dobutamine and other drugs. Preliminary studies indicate that the concomitant administration of Dobutamine and nitroprusside increases cardiac output and usually reduces pulmonary capillary wedge pressure more than either of these drugs alone. Animal studies indicate that dobutamine may prove ineffective in patients recently treated with β-adrenoreceptor-blocking drugs. In such cases, peripheral vascular resistance may increase.
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