Dorio Dosage/Direction for Use

DORIO is administered by IV infusion. (See Table 1.)

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Duration of therapy includes a possible switch to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated. (See Table 2.)

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DORIO is removed by hemodialysis; data are insufficient to recommend dosage adjustment in patients undergoing hemodialysis.
Preparation for administration: Aseptic technique must be observed when preparing solutions of DORIO.
Reconstitute the vial with 10 mL of sterile water for injection or sodium chloride 0.9% injection (normal saline) and gently shake to form a suspension. The reconstituted suspension is not for direct injection. It is stable for up to 1 hour prior to transfer and dilution in the infusion bag.
Withdraw the suspension using a syringe with needle and add it to an infusion bag containing 100 mL of normal saline or 5% dextrose, gently shake until clear. (for 500 mg dose)
For 250 mg dose, remove 55 mL of this solution from the bag and discard. Infuse the remaining solution.
Following dilution, store at controlled room temperature or under refrigeration should be completed according to the times in the table: see Table 3.

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Reconstituted and diluted DORIO solutions should be inspected visually for particulate matter and discoloration. Final solutions range from clear and colorless to clear, slightly yellow solution. DORIO should not be admixed or added to solutions containing other drugs. It should not be frozen.