Sign Out
Sensitivity Reactions: Serious and occasionally fatal hypersensitivity reactions (e.g., anaphylaxis) and serious skin reactions reported with β-lactams. Cross-allergenicity occurs among β-lactams antibiotics, including penicillins and cephalosporins. If an allergic reaction occurs, discontinue DORIO. Serious active hypersensitivity (anaphylactic) reactions require emergency treatment.
Clostridium difficile-associated Diarrhea and Colitis (CDAD): Treatment with DORIO alters normal colon flora and may permit overgrowth of Clostridium difficile. C. difficile-associated diarrhea and colitis (also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) has been reported with nearly all anti-infectives and may range in severity from mild diarrhea to fatal colitis. Consider in all patients who present with diarrhea following DORIO use, since CDAD has been reported to occur more than 2 months after administration of antibacterial agent.
Selection and Use of Anti-infectives: To reduce development of drug-resistant bacteria and maintain effectiveness of DORIO, use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.
Pneumonitis with inhalational use: When doripenem has been used investigationally via inhalation, pneumonitis has occurred. Do not administration DORIO by this route.
