Children: Neonates up to the age of 7 days: an initial dose of 15 mg/kg should be given followed by 10 mg/kg every 12 hours.
Neonates up to the age of 1 month: an initial dose of 15 mg/kg should be given followed by 10 mg/kg every 8 hours.
Infants older than 1 month of age: the recommended dosage is 40 mg/kg daily, divided to individual doses given every 6 or 12 hours.
Adults: The usual intravenous infusion dose is 500 mg every 6 hours or 1 g every 12 hours. Each dose should be administered slowly at the rate not exceeding 10 mg/min over a period of at least 60 minutes or longer.
In patients with impaired renal function, the dose and/or dose intervals should be adjusted carefully to the severity of impairment.
An initial dose of 15 mg/kg body weight should be given, later on the dose interval may be prolonged depending on creatinine clearance. (See table.)
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