Compensated liver disease Nucleoside-naïve patients 0.5 mg once daily.
Patient w/ renal impairment 30 to <50 mL/min 0.25 mg once daily or 0.5 mg once every 48 hr,
10 to <30 mL/min 0.15 mg once daily or 0.5 mg once every 72 hr,
<10 mL/min, on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) 0.05 mg once daily or 0.5 mg once every 5-7 days.
Lamivudine-refractory patients 1 mg once daily.
Patients w/ renal impairment 30 to 50 mL/min 0.5 mg once daily or 1 mg once every 48 hr,
10 to <30 mL/min 0.3 mg once daily or 1 mg once every 72 hr,
<10 mL/min, or hemodialysis or CAPD 0.1 mg once daily or 1 mg once every 5-7 days.
Decompensated liver disease 1 mg once daily.
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