Encavir Dosage/Direction for Use

Compensated liver disease: Nucleoside-naive patients: Usual dosage: 0.5 mg once daily.
Lamivudine-refractory patients (history of hepatitis B viremia while receiving lamivudine or with known lamivudine resitance mutations): Usual dosage: 1 mg once daily.
Decompensated liver disease: 1 mg once daily.
Renal impairment: Dosage of entecavir should be adjusted in patients with pre-existing renal impairment (i.e. baseline creatinine clearance less than 50 mL/minute), including patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). (See Table.)

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Mode of Administration: ENCAVIR is administered orally. Because presence of food in the GI tract may decrease the rate and extent of absorption, ENCAVIR should be administered on an empty stomach at least 2 hours before or 2 hours after meals.
ENCAVIR oral solution contains 0.05 mg of entecavir per milliliter. Therefore, 10 mL of the oral solution provide a 0.5 mg dose and 20 mL provide a 1 mg dose of entecavir.
Patients undergoing hemodialysis should receive the entecavir dose after the dialysis session.