Exsirox Overdosage

Adult: Chronic iron overload due to transfusions: Maximum dose 40 mg/kg/day.
Chronic iron overload in non-transfusions-dependent thalassemia syndromes: Maximum dose 20 mg/kg/day.
Pediatric: Chronic iron overload due to transfusions: 2 years and older: Maximum dose 40 mg/kg/day.
Chronic iron overload in non-transfusions-dependent thalassemia syndromes: 10 years and older: Maximum dose 20 mg/kg/day.
Symptoms: Overdose data are limited. Signs and symptoms of an acute overdose are anticipated to be similar to excessive pharmacologic adverse events. Hepatitis was reported in one patient who received 2 to 3 times the prescribed dose of Deferasirox over a period of several weeks. In iron overloaded beta-thalassemic patients, single doses up to 80 mg/kg have been tolerated with nausea and diarrhea noted. Single doses up to 40 mg/kg were tolerated in healthy volunteers.
Treatment: MANAGEMENT OF MILD TO MODERATE TOXICITY: Treatment is symptomatic and supportive. MANAGEMENT OF SEVERE TOXICITY: Treatment is symptomatic and supportive. Severe anaphylaxis should be treated with antihistamines, corticosteroids, and epinephrine. Myelosuppression has been reported. Monitor serial CBC with differential. For severe neutropenia, administer colony stimulating factor (eg; filgrastim, sargramostim). Transfusions as needed for severe thrombocytopenia, bleeding.