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Three time a day dosing regimen: Tablets: Usual dosages for the treatment of infection.
Adults and children over 12 years: Mild - Moderate infections: One Fleming 375 mg tablet three times a day.
Severe infections: 1 Fleming 625 mg tablet three times a day.
Children: Under one year: #.
1 year - 6 years: 5 ml Fleming 156.25 mg/5 ml Oral suspension three times a day.
Over 6 years: 10 ml Fleming 156.25 mg/5 ml Oral suspension three times a day.
# The usual recommended daily dosage is 25 mg/kg/day* in divided doses every 8 hours. In more serious infections, the dosage may be increased to 50 mg/kg/day* in divided doses every 8 hours. There is insufficient experience with Fleming Oral suspension to make dosage recommendations for children under 2 months old.
* Each 25 mg Fleming provides 20 mg amoxicillin and 5 mg clavulanic acid.
Fleming 375 mg, 625 mg tablets are not recommended for children of 12 years and under.
Dosage in dental infections: (e.g. dentoalveolar abscess).
Adults and children over 12 years: One Fleming 375 mg tablet three times a day for five days.
Dosage in renal impairment: Adults: See Table 1.
Click on icon to see table/diagram/imageChildren: Similar reductions in dosage should be made for children.
For very young children with immature renal function Fleming Oral suspension is not recommended. For children with a GFR of <30 ml/min Fleming Oral suspension is not recommended.
Twice a day dosing regimen: Usual dosages for the treatment of infection.
Adults: Mild - moderate infections: One Fleming 625 mg tablet twice a day.
Severe infections: One Fleming 1 g tablet twice a day.
Dosage in dental infections: (e.g. dentoalveolar abscess).
Adults and children over 12 years: One Fleming 625 mg tablet two times a day for five days.
Fleming 625mg and 1 g tablets are not recommended in children of 12 years and older.
Children: Fleming Oral suspensions are recommended.
The usual recommended daily dosage is expressed as amoxicillin/clavulanic acid: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsillitis, lower respiratory tract infections and skin and soft tissue infections).
45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections e.g. otitis media and sinusitis, lower respiratory tract infections e.g. bronchopneumonia and urinary tract infections).
The tables as follows give guidance for children.
Children over 2 years: See Table 2.
Click on icon to see table/diagram/imageDosage in renal impairment: Adults: The Fleming 1 g tablet should only be used in patients with a glomerular filtration rate of >30ml/min. (See Table 3.)
Click on icon to see table/diagram/imageChildren: Similar reductions in dosage should be made for children.
For very young children with immature renal function Fleming Oral suspension is not recommended. For children with a GFR of <30 ml/min Fleming Oral suspension is not recommended.
Children aged 2 months to 2 years old: It is recommended that children under 2 years of age are dosed based upon body weight. This is insufficient data available to make dosage recommendations for children under 2 months old. The table as follows shows the individual dose recommended to be given twice a day. The dose can also be given three or four times a day based upon maintaining the same amount of antibiotic per day. (For example if given four times a day in mild to moderate infection to a 10 kg child, the volume per dose of Fleming oral suspension 457 mg/5 ml would be 0.8 ml). (See Table 4.)
Click on icon to see table/diagram/imageDosage in hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
Oral Administration: Tablets should be swallowed whole without chewing. If required, tablets may be broken in half and swallowed without chewing. To minimise potential gastrointestinal intolerance, administer at the start of a meal. The absorption of co-amoxiclav is optimised when taken at the start of a meal. Treatment should not be extended beyond 14 days without review.
