Forxiga Dosage/Direction for Use

Recommended Dosage: Type 2 diabetes mellitus: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Monotherapy and Add-On Combination Therapy: The recommended dose of FORXIGA is 10 mg once daily as monotherapy or as add-on to combination therapy with metformin (with or without a sulfonylurea), a thiazolidinedione, a sulfonylurea, a DPP4-inhibitor (with or without metformin), or insulin (with or without oral antidiabetic therapy, either metformin plus insulin dual therapy or metformin plus sulfonylurea plus insulin triple therapy).
Initial Combination Therapy: The recommended starting doses of FORXIGA and metformin when used as initial combination therapy are 10 mg FORXIGA plus 500 mg metformin once daily. Patients with inadequate glycemic control on this dose should further have their metformin dose increased according to approved local label guidelines.
Heart failure: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Chronic kidney disease: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Special Populations: Patients with renal impairment: No dosage adjustment for FORXIGA is required based on renal function.
The glucose lowering efficacy of FORXIGA is reduced in patients with eGFR <45 mL/min/1.73 m² (see Precautions and Pharmacology: Pharmacodynamics under Actions). Therefore, if eGFR falls below 45 mL/min/1.73 m², additional glucose lowering treatment should be considered in patients with diabetes mellitus.
Patients with hepatic impairment: No dosage adjustment for FORXIGA is necessary for patients with mild, moderate or severe hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
Pediatric and adolescent patients: Safety and effectiveness of FORXIGA in pediatric and adolescent patients have not been established.
Geriatric Patients: No dosage adjustment for FORXIGA is required based on age (see Pharmacology: Pharmacodynamics under Actions). Older patients are more likely to have impaired renal function. The renal function recommendations provided for all patients also apply to elderly patients (see Precautions).