IV infusion Administer over 60 min or longer by intermittent IV infusion, or over 24-hr by slow IV drip.
Adult w/ normal renal function 1 g or 10-15 mg/kg every 12 hr.
Prophylaxis for bacterial endocarditis in dental, oral or upper resp tract surgery 1 g 1 hr before surgery,
GI/GU procedure 1 g + 1.5 mg/kg gentamicin 1 hr prior surgery.
Childn & infant >1 mth 40 mg/kg daily in divided doses every 6 hr.
Staph CNS infection 60 mg/kg daily in divided doses every 6 hr.
Prophylaxis for bacterial endocarditis in dental, oral, or upper resp tract surgery 20 mg/kg 1 hr prior to procedure,
GI/GU procedure 20 mg/kg + gentamicin 2 mg/kg 1 hr prior to surgery.
Neonate: Postnatal age >7 days weighing ≥1,200 g 10 mg/kg divided every 8 hr,
<1,200 g 15 mg/kg every 24 hr.
Postnatal age ≤7 days weighing >2,000 g 15 mg/kg every 12 hr,
1,200-2,000 g 10 mg/kg every 12 hr,
<1,200 g 15 mg/kg every 24 hr.
Renal impairment w/ CrCl >60 mL/min Initially 1 g or 10-15 mg/kg every 12 hr,
CrCl 40-60 mL/min Initially 1 g or 10-15 mg/kg every 24 hr.
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