Glutril Mechanism of Action

Pharmacology: Pharmacodynamics: Glucosamine sulfate is capable of stimulating proteoglycans synthesis and decreasing activity of catabolic enzyme such as Matrix Metalloproteinases (MMP) resulting in the delay deterioration of chondrocyte.
Glucosamine sulfate is capable of stimulating proteoglycan synthesis, inhibiting the degradation of proteoglycans, and stimulating the regeneration of experimentally-induced cartilage damage. Some experts also believe glucosamine sulfate might promote the incorporation of sulfur into cartilage.
Pharmacokinetics: In humans, about 90 percent of glucosamine, administered as an oral dose of glucosamine sulfate, is absorbed from the digestive tract. After an oral dose, glucosamine concentrations in the liver, where it is either incorporated into plasma proteins, degrade into smaller molecules, or utilized for other biosynthetic process. The drug is extensively metabolized by first-pass metabolism in the liver which result in low bioavailability (26%). At present, there is no information on the amount of the drug distributed to the joint. The elimination half-life is 2.1 hours. Most of the drug is eliminated through urine and small amount of glucosamine or its derivatives eliminated in the feces.