In combination w/ corticosteroids &/or other immunosuppressive agents to enhance survival of organ transplants & reduce corticosteroid requirements of renal transplant recipients. Alone or in combination w/ corticosteroids for severe RA, SLE, dermatomyositis & polymyositis, autoimmune chronic active hepatitis & haemolytic anemia, pemphigus vulgaris, polyarteritis nodosa, chronic refractory idiopathic thrombocytopenic purpura.
Hypersensitivity. Patient w/ infection; Lesch-Nyhan syndrome; thiopurine methyltransferase (TPMT) enzyme deficiency. Increased fertility in renal transplant recipients. Signs or symptoms of bone marrow suppression eg, inexplicable bruising or bleeding, infection. Monitor blood counts & adjust dosage for bone-marrow toxicity. Avoid sunlight exposure in patients w/ increased risk of skin cancer. Lactose intolerance. Renal or liver impairment. Women of childbearing potential. Not to be given during pregnancy. Not recommended during lactation.
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