A number of medicines interact with azathioprine and should not be used concomitantly. However, a few of them can be used concomitantly under special precautions. In this case, the doctor may want to change the dose, or other precautions may be necessary. When the patient is taking Imuprin, it is especially important that the doctor and pharmacist know if the patient is taking any of the following: Allopurinol, oxipurinol, thiopurinol, succinylcholine, tubocurarine, warfarin, cytostatics, penicillamine, ACE inhibitors (captopril), cimetidine, indomethacin, vaccines, olsalazine, mesalazine, sulphasalazine, furosemide.
The immunosuppressive activity of Imuprin could result in an atypical and potentially deleterious response to live vaccines and so administration of live-vaccines to patients receiving Imuprin therapy is contra-indicated.