Inovelon Dosage/Direction for Use

Pediatric patients (1 year to less than 17 years): The recommended starting daily dose of INOVELON in pediatric patients with Lennox-Gastaut Syndrome is approximately 10 mg/kg administered in two equally divided doses. The dose should be increased by approximately 10 mg/kg increments every other day until a maximum daily dose of 45 mg/kg, not to exceed 3200 mg, administered in two equally divided doses, is reached. It is not known whether doses lower than the target doses are effective.
Adults (17 years and older): The recommended starting daily dose of INOVELON in adults with Lennox-Gastaut Syndrome is 400 to 800 mg per day administered in two equally divided doses. The dose should be increased by 400-800 mg every other day until a maximum daily dose of 3200 mg, administered in two equally divided doses, is reached. It is not known whether doses lower than 3200 mg are effective.
Administration Information: Administer INOVELON with food. INOVELON film-coated tablets can be administered whole, as half tablets or crushed.
Dosing in Patients Undergoing Hemodialysis: Hemodialysis may reduce exposure to a limited (about 30%) extent. Accordingly, adjusting the INOVELON dose during the dialysis process should be considered (see Pharmacology under Actions).
Dosing in Patients with Hepatic Disease: Use of INOVELON in patients with hepatic impairment has not been studied. Therefore, use in patients with severe hepatic impairment is not recommended. Caution should be exercised in treating patients with mild to moderate hepatic impairment (see Precautions).
Dosing in Patients Taking Valproate: Patients taking valproate should begin INOVELON at a dose lower than 10 mg/kg per day in pediatric patients or 400 mg per day in adults (see Interactions).