Adult Regimen 1 125 mg/m2 by IV infusion over 90 min on days 1, 8, 15 & 22 followed by leucovorin & 5-FU. Repeat cycle course every 6 wk. Regimen 2 180 mg/m2 by IV infusion over 90 min on days 1, 15 & 29 followed by leucovorin & 5-FU on days 1, 2, 15, 16, 29 & 30. Next cycle course begins on day 43.
Early & late forms of diarrhea. Ensure fluid & electrolyte replacement upon dehydration. Severe myelosuppression. Monitor for signs of inflammation in infusion site, WBC w/ differential Hb & platelet count before each dose. Administer antiemetic agents 30 min prior to treatment. Consider prophylactic & therapeutic administration of atropine SC. Patients who had previously received pelvic/abdominal irradiation. Hepatic dysfunction. Gilbert's syndrome. Women of childbearing potential should avoid becoming pregnant. Pregnancy & lactation. Elderly.
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