Most commonly reported adverse effects are gastrointestinal disturbances, including nausea, vomiting, flatulence, epigastric pain, constipation, diarrhea, anorexia, and dyspepsia. Adverse effects also include edema, tachycardia, drowsiness, insomnia, headache, erythema, pruritus or skin reaction, leg swelling, flushing, fatigue, and hypertension, but rarely occur.