Lantus Drug Interactions

In order to avoid possible interactions with other medicines, inform the physician or pharmacist about any other current treatment.
Certain medicines affect glucose metabolism and may require insulin dose adjustment and particularly close monitoring.
An increase in the blood-sugar-lowering effect and in susceptibility to hypoglycaemia may occur in concomitant use of, e.g., oral antidiabetics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates, or sulfonamide antibiotics.
A decrease in the blood-sugar-lowering effect may occur in concomitant use of corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, oestrogens and progestogens (e.g. in oral contraceptives), phenothiazine derivatives, somatropin, sympathomimetic agents such as [epinephrine (adrenaline), salbutamol, terbutaline], thyroid hormones, atypical antipsychotic medicinal products (e.g. clozapine and olanzapine) and protease inhibitors.
Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood-sugar-lowering effect of insulin. Pentamidine may cause hypoglycaemia, sometimes followed by hyperglycaemia. Moreover, beta-blockers, in common with other sympatholytic medicines (e.g., clonidine, guanethidine, reserpine) may weaken or even suppress entirely the warning symptoms of a hypoglycaemic reaction.