Overdose and Treatment: Overdosage may give rise to clinical signs and symptoms of hypokalemia, including irritability, confusion, delayed thought process, muscle weakness, hyporeflexia, and eventually frank paralysis. Apnea may be a serious consequence of this progression. Cardiac arrhythmia may occur. Appropriate measures should be taken to correct serum electrolytes (potassium, calcium). The resin should be removed from the gastrointestinal tract by appropriate use of laxatives or enema.