1. Norepinephrine injection should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOIs) or antidepressants of the triptyline or imipramine types because severe prolonged hypertension may result.
2. Norepinephrine injection contains sodium metabisulfite, a sulfite that may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people.