Sign Out
Cephalosporins, Enflurane, Methoxyflurane, Vancomycin: Risk of neprotoxicity may increase above that with aminoglycoside alone. Monitor patients.
Indomethacin IV: In preterm infants, the use of indomethacin for closure of patent ductus arteriosus resulted in aminoglycoside accumulation in one study.
Loop diuretics: Auditory toxicity appears to increase during concomitant use. Hearing loss of vary degrees may occur; it may be irreversible. Monitor patients.
Neuromuscular blockers, depolarizing and non-depolarizing: The neuromuscular blocking effects are enhanced by aminoglycosides. Prolonged respiratory, depression may occur.
Penicillins: Synergism of these agents is well documented; however, certain penicillins may inactivate certain aminoglycosides. The problein may be greatest in vitro.
Polypeptide antibiotics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
