Nelin Overdosage

Symptoms: Auditory and vestibular toxicities have been associated with aminoglycoside overdose. These toxicities may occur in patients treated > 10 days, in patients with reduced renal function, in dehydrated patients, or patients receiving medications with additive auditory toxicities. These patients may not have signs or symptoms or may experience dizziness, tinnitus, vertigo and lose of high-tone acuity as ototoxicity progresses. Ototoxicity signs and symptoms may not begin to occur until long after the drug has been discontinued.
Neuromuscular blockage or respiratory paralysis may occur following aminoglycoside administration. If neuromuscular blockade occurs, it may be reversed by the administration of calcium salts but mechanical assistance may be necessary.
Treatment: The initial treatment intervention is to establish an airway and ensure oxygenation and ventilation. Adequately hydrate patients and carefully monitor fluid balance, Ccr and plasma levels.
In the even of overdose or toxic reactions, hemodialysis or peritoneal dialysis will aid in the removal of netilmicin sulfate from the blood. Hemodialysis is preferable because it is more efficient in reducing serum levels.