Adult Neuropathic pain Initially 150 mg daily. May be increased to 300 mg daily after 3-7 days. Max: 600 mg daily after additional 7-day interval.
Diabetic peripheral neuropathy Initially 150 mg daily in 3 divided doses. May be increased to max of 300 mg daily in 3 divided doses w/in 1 wk.
Neuropathic pain associated w/ spinal cord injury Initially 75 mg bid. May be increased to 150 mg bid w/in 1 wk. May further increase up to max of 600 mg daily (300 mg bid) after 2-3 wk.
Postherpetic neuralgia Initially 150 mg daily in divided doses (75 mg bid or 50 mg tid). May be increased to 300 mg daily w/in 1 wk. May further increase up to max of 600 mg daily in divided doses (300 mg bid or 200 mg tid) after 2-4 wk.
GAD Initially 150 mg daily in 2-3 divided doses. May be increased in increments of 150 mg daily at wkly intervals up to usual dose of 300 mg daily. May further increase up to 600 mg daily.
Epilepsy Initially 150 mg daily in 2-3 divided doses. May be increased up to max of 600 mg daily at wkly intervals.
Fibromyalgia Initially 75 mg bid. May be increased to 150 mg bid w/in 1 wk. Max: 450 mg daily.
Renal impairment w/ CrCl ≥60 mL/min 150, 300, 450 or 600 mg daily in 2-3 doses,
30-60 mL/min 75, 150, 225 or 300 mg daily in 2-3 doses,
15-30 mL/min 25-50, 75, 100-150 or 150 mg daily in 1-2 doses,
<15 mL/min 25, 25-50, 50-75 or 75 mg daily as single dose. Supplementary dose post-hemodialysis (as single additional dose): 25 mg daily schedule: 25 mg or 50 mg; 25-50 mg daily schedule: 50 mg or 75 mg; 50-75 mg daily schedule: 75 mg or 100 mg; 75 mg daily schedule: 100 mg or 150 mg.
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