Nervica Dosage/Direction for Use

Neuropathic pain: Initial: 150 mg/day. Based on individual response and tolerability, dosage may be increased to 300 mg/day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg/day after an additional 7-day interval.
Diabetic peripheral neuropathy: Initial 150 mg/day in 3 divided dose; may increase to maximum dose of 300 mg/day in 3 divided doses within 1 week based on efficacy and tolerability.
Neuropathic pain associated with spinal cord injury: Initial 75 mg twice daily; may increase within 1 week based on response and tolerability to 150 mg twice daily; after 2 to 3 weeks, may further increase up to a maximum of 600 mg/day (300 mg twice daily).
Postherpetic neuralgia: Initial 150 mg/day in divided doses (75 mg twice daily or 50 mg 3 times daily); may increase to 300 mg/day within 1 week based on response and tolerability; after 2 to 4 weeks, may further increase up to the maximum dose of 600 mg/day in divided doses (300 mg twice daily or 200 mg 3 times daily).
Epilepsy: Initial 150 mg/day in 2 to 3 divided doses, may increase based on response and tolerability at weekly intervals up to a maximum dose of 600 mg/day.
Generalized anxiety disorder: Initial 150 mg/day in 2 to 3 divided doses; may increase based on response and tolerability at weekly intervals in increments of 150 mg/day up to a usual dose of 300 mg/day. May further increase up to 600 mg/day.
Fibromyalgia: Initial 75 mg twice daily; may increase to 150 mg twice daily within 1 week based on response and tolerability; maximum dose 450 mg/day.
Dosage adjustment in renal impairment: See table.

Click on icon to see table/diagram/image

Supplementary dosage post-hemodialysis (as a single additional dose): 25 mg/day schedule: Single supplementary dose of 25 mg or 50 mg.
25 to 50 mg/day schedule: Single supplementary dose of 50 mg or 75 mg.
50 to 75 mg/day schedule: Single supplementary dose of 75 mg or 100 mg.
75 mg/day schedule: Single supplementary dose of 100 mg or 150 mg.
Dosage adjustment in Hepatic impairment: No dosage adjustment necessary.
Discontinuation: In patients receiving pregabalin chronically, unless safety concerns require a more rapid withdrawal, pregabalin should be withdrawn gradually over ≥ 1 week to minimize the potential of increased seizure frequency or other withdrawal symptoms.
Administration: May be administered with or without food.