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Excessive intake of One-Alpha may lead to the development of hypercalcaemia, however, the effect is reversed rapidly on withdrawal.
In severe cases of hypercalcaemia general supportive measures should be undertaken: Keep the patient well hydrated by IV infusion of saline (force diuresis), measure electrolytes, calcium, and renal functions indices, assess electrocardiographic abnormalities, especially on patients using digitalis.
More specifically, treatment with glucocorticosteroids, loop diuretics, bisphosphonates, calcitonin and eventually haemodialysis with low calcium contents should be considered.
