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Hypersensitivity to warfarin or to any of the excipients.
Pregnancy (see Use in Pregnancy & Lactation).
Bleeding tendency (von Willebrand disease, hemophilia, thrombocytopenia and platelet function disorders).
Severe hepatic insufficiency and hepatic cirrhosis.
Untreated or uncontrolled hypertension.
Recent intracranial bleeding. Other conditions predisposing to intracranial bleeding eg, aneurysms.
Tendency to fall.
Surgery of the central nervous system or the eye.
Conditions predisposing to the gastrointestinal or urinary tract bleeding eg, previous gastrointestinal bleeding complications, diverticulosis or malignancies.
Infectious endocarditis (see Precautions), pericarditis or pericardial effusion.
Dementia, psychoses, alcoholism and other situations where the compliance may be poor and the treatment cannot be carried out safely in practice.
