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Sensitivity Reactions: Anaphylaxis has been reported with the use of IV pantoprazole sodium. Immediate medical intervention and drug discontinuance are required if anaphylaxis or other severe hypersensitivity reactions occurs.
GI Effects: In long term animal studies, pantoprazole caused rare types of GI tumors, although the relevance of these finding to humans is unknown.
Respiratory Effects: Administration of proton-pump inhibitors has been associated with an increased risk for developing certain infections (e.g. community-acquired pneumonia).
Hepatic Effects: Mild, transient elevation of serum ALT (SGPT) have been reported with oral pantoprazole therapy. Serum ALT increase exceeding 3 times the upper limit of normal occurred in 0.4% of patients receiving pantoprazole 40 mg daily in short-term studies.
Use in Children: Safety and efficacy in children younger than 18 years of age have not been established.
Use in the Elderly: No dosage adjustment is necessary in geriatric patients.
