In compliance with local requirements, vaccination should be preceded by a review of the medical history and a clinical examination. As with all injectable vaccines, appropriate medical care should be readily available in case of a rare anaphylactic reaction after vaccination.
In the case of acute severe febrile illness, immunosuppressive treatment or immunodeficiency, vaccination should be postponed. Nevertheless, vaccination should be considered in HIV-infected persons or those with chronic immunodeficiency disorder.
As with any vaccines, Pertagen should be administered with caution to subjects who had high body temperature (≤40°C) without any identifiable causes within 48 hours after a previous immunization with any pertussis vaccines. Pertagen should be given with caution in individuals receiving anticoagulant therapy or those with thrombocytopenia or any coagulation disorder because bleeding at injection site may occur after intramuscular injection.