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Hypersensitivity to clopidogrel or any of the excipients of Plavix. Severe liver impairment; active pathological bleeding eg, peptic ulcer or intracranial haemorrhage. Breastfeeding (see Use in lactation as follows).
Use in Lactation: Studies in rats have shown that clopidogrel and/or its metabolites are excreted in the milk. It is not known whether Plavix is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to a nursing woman.
