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Contraindications for use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia: Hypersensitivity to the active substance or to murine proteins, or to any of the other excipients.
Active, severe infections (see Precautions).
Patients in a severely immunocompromised state.
Contraindications for use in rheumatoid arthritis, granulomatosis with polyangiitis and microscopic polyangiitis: Hypersensitivity to the active substance or to murine proteins, or to any of the other excipients.
Active, severe infections (see Precautions).
Patients in a severely immunocompromised state.
Severe heart failure (New York Heart Association Class IV) or severe, uncontrolled cardiac disease (see Precautions regarding other cardiovascular diseases).
