300 mg: Soride 300 is a white, round, biconvex compressed tablet containing 300 mg of sodium chloride equivalent to 5.13 mmol of sodium.
600 mg: Soride 600 is a white, round, biconvex compressed tablet containing 600 mg of sodium chloride equivalent to 10.26 mmol of sodium.
Excipient/Inactive Ingredient: PEG 6000.
Pharmacology: Pharmacodynamics/Pharmacokinetics: Sodium chloride is well absorbed from the gastrointestinal tract. Excess sodium is mainly excreted by the kidney, and small amounts are lost in the faeces and sweat.
For the treatment of deficiency of sodium ions in salt-losing condition in elderly or patients who receive some diuretic-induced sodium loss.
Recommended Dose: Adults: 300-600 mg or 1-2 tablets, 2-3 times a day or as directed by a physician.
Mode of Administration: The tablets should be swallowed whole with water.
Excessive intake of sodium chloride can result in hypernatraemia. Symptoms of hypernatraemia see Adverse Reactions. In patients with mild sodium excess, giving water by mouth and restricting sodium intake is sufficient. In the event of recent acute oral overdose of sodium chloride, gastric lavage should be carried out along with general symptomatic and supportive treatment. Serum-sodium concentrations should be measured. In more severe conditions, glucose 5% may be given by slow intravenous infusion. Alternatively, some recommend the use of sodium chloride 0.9% if volume depletion is severe. Care is required, as too rapid correction can induce cerebral oedema, particularly in chronic conditions. If the total body sodium is too high, loop diuretics may be used to increase sodium excretion, with fluid losses being replaced by an infusion of glucose 5% and potassium chloride. It has also been suggested that dialysis may be necessary if there is significant renal impairment, if the patient is moribund, or if the serum-sodium concentration is greater than 200 mmol/litre.
Hypersensitivity to sodium chloride or any component in the formulation; hypertonic uterus, hypernatremia, fluid retention.
Soride should be used with caution to patients with hypertension, heart failure, peripheral or pulmonary oedema, impaired renal function, pre-eclampsia or other conditions associated with sodium retention. Soride should be administered with adequate water to prevent hypernatraemia.
Insufficient information is available on the use of sodium chloride in pregnancy and breast feeding. Use of Soride in pregnancy or while breastfeeding is recommended only when potential benefits outweigh potential risk.
Excessive administration of sodium salts may cause electrolyte imbalances. Hypernatraemia is usually associated with inadequate water intake, or excessive water losses. It rarely occurs with therapeutic doses of sodium chloride. The most serious effect of hypernatraemia is dehydration of the brain which causes somnolence and confusion progressing to convulsions, coma, respiratory failure, and death. Other symptoms include thirst, reduced salivation and lachrymation, fever, sweating, tachycardia, hypertension or hypotension, headache, dizziness, restlessness, irritability, weakness, and muscular twitching and rigidity. Gastro-intestinal effects associated with acute oral ingestion of sodium chloride include nausea, vomiting, diarrhea, and abdominal cramps. Excessive administration of chloride salts may cause a loss of bicarbonate with an acidifying effect.
Decreased levels of lithium.
Store below 30°C. Protect from heat and moisture.
A12CA01 - sodium chloride ; Belongs to the class of sodium-containing preparations. Used as dietary supplements.
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