IV/SC Adult Treatment of acute DVT w/ or w/o PE 1 mg/kg 12 hr or 1.5 mg/kg every 24 hr SC at the same time every day for inpatient;
w/ PE 1 mg/kg SC every 12 hr for outpatient. Ave duration of therapy: 7 days. Up to 17 days. Initiate warfarin when appropriate usually w/in 72 hr of treatment.
Treatment of acute STEMI 30 mg single IV bolus + 1 mg/kg SC followed by 1 mg/kg followed by 1 mg/kg SC every 12 hr. Initiate treatment between 15 min before or 30 min after start of thrombolytic (fibrin-/non-fibrin- specific) therapy. Max dose: 100 mg for 1st 2 doses, only followed by 1 mg/kg for the remaining dose. Duration of therapy: May continue up to 8 days or until revascularization.
Treatment of ischemic complications of unstable angina & NSTEMI 100 anti-Xa IU/kg by SC inj bid at 12-hr interval, in combination w/ aspirin (recommended doses: 75-325 mg PO, following a min loading dose of 160 mg). Recommended duration of treatment: 2-8 days, until the patient is clinically stable.
Prevention of thrombus formation (clotting) in the extracorporeal circulation during hemodialysis 1 mg/kg (100 u/kg) into arterial line of circuit at the beginning of dialysis. May give further dose of 0.5-1 mg/kg (50-100 u/kg) if required.
PCI 0.3 mg/kg IV bolus if last SC administration was given >8 hr before balloon inflation.
Prophylaxis of post-op DVT &/or PE in abdominal surgery 40 mg once daily SC inj w/ initial dose given 2 hr prior surgery. Duration of therapy: 7-10 days up to 12 days;
hip or knee replacement surgery 30 mg SC every 12 hr initially given 12-24 hr prior surgery provided that hemostasis has been established. Alternative dose for hip replacement surgery: 40 mg every 24 hr initially given 12 (±3) hr prior surgery. Following initial phase of thromboprophylaxis in hip replacement surgery, continued prophylaxis w/ 40 mg SC once daily for 3 wk. Duration of therapy: 7-10 days up to 14 days.
Prophylaxis of DVT in patients w/ acute illness 40 mg once daily. Duration of therapy: 6-11 days, up to 14 days.
Prophylaxis of ischemic complications of unstable angina & NSTEMI 1 mg/kg SC every 12 hr. Duration of therapy: 2-8 days. Concomitant therapy: 100-325 mg aspirin PO once daily.
Elderly ≥75 yr Acute STEMI Initially 0.75 mg/kg SC every 12 hr. Max dose: 75 mg for 1st 2 doses only, followed by 0.75 mg/kg for remaining doses.
Severe renal impairment (CrCl <30 mL/min) Acute DVT w/ or w/o PE (inpatient) & w/o PE (outpatient) in conjunction w/ aspirin 1 mg/kg SC once daily.
Acute STEMI in conjunction w/ aspirin Patients ≥75 yr 1 mg/kg SC once daily;
<75 yr 30 mg single IV bolus + 1 mg/kg SC, followed by 1 mg/kg SC once daily.
Prophylaxis of DVT in abdominal surgery/hip or knee replacement surgery; during acute illness 30 mg SC once daily;
ischemic complications of unstable angina/NSTEMI when co-administered w/ aspirin 1 mg/kg SC once daily.
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