Pregnancy: Pregnancy category C.
Flucytosine was shown to be teratogenic in rats. There are no adequate or controlled studies to date using Flucytosine in pregnant women and the drug should be used during pregnancy only when potential benefits justify the potential risks to the fetus.
Lactation: It is not known whether Flucytosine is excreted into human breast milk. Because of the potential for serious adverse effects in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.