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Hypersensitivity or intolerance to ursodiol or any of the components of the formulations.
Ursodiol will not dissolve calcified cholesterol stones, radiopaque stones or radiolucent bile pigment stones. Hence, patients with such stones are not candidates for ursodiol therapy.
Patients with compelling reasons for cholecystectomy including unremitting acute cholecystitis, cholangitis, biliary obstruction, gallstone pancreatitis or biliary GI fistula are not candidates for ursodiol therapy.
Allergy to bile acids.
