Utrogestan Dosage/Direction for Use

Posology: The recommended dosages must be strictly respected in all therapeutic indications.
Whatever the indication and route of administration (oral or vaginal), the dosage should never exceed 200 mg per intake.
Oral route: In Progesterone insufficiency the average dosage is from 200 to 300 mg micronised Progesterone per day. This medicinal product should be taken without food preferably in the evening before going to bed.
In pre-menstrual disorders, amenorrhea (primary & secondary) and bleeding due to fibroma, the usual treatment regimen is 200 to 300 mg per day: 200 mg in a single evening dose before retiring, or 300 mg in 2 dividing doses (200 mg before going to bed and 100 mg in the morning if necessary), 10 days per cycle, usually from the 17th to the 26th day inclusive.
In hormone replacement therapy in women receiving isolated estrogen there is an increased risk of endometrial cancer which should be countered by Progesterone administration.
One dose (100 mg) can be given at bedtime from day 1 to day 25 of each therapeutic cycle, withdrawal bleeding being less with this treatment schedule.
Two doses (each of 100 mg, or a single dose of 200 mg) in the evening before retiring, 12 to 14 days per month, or the last two weeks of each treatment sequence. This treatment must be followed by the total discontinuation of any replacement therapy for approximately one week during which a deprivation haemorrhage is often observed.
Vaginal route: Each capsule must be inserted deep in the vagina.
Supplementation of the luteal phase during IVF cycles: The recommended dosage is from 400 to 600 mg/day, in two to three divided doses, from the day of hCG injection up until the 12^th week of pregnancy.
Threatened miscarriage or prevention of habitual miscarriage due to luteal phase insufficiency: the recommended dosage is from 200 to 400 mg/day in two divided doses up until the 12^th week of pregnancy.
Preterm labour: Women with a history of preterm labour - 100 mg/day until 36^th week of pregnancy. Women with cervix shorter than 15 mm detected at 22-26 weeks - 200 mg daily until the 36^th week of pregnancy.