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Food interaction: Concomitant food ingestion increased the bioavailability of Micronised Progesterone Capsules.
Drug - Drug interaction: Metabolism of Progesterone Capsules by human liver microsomes was inhibited by ketoconazole (IC50 <0.1 μM ketoconazole is a known inhibitor of cytochrome P450 3A4. These data therefore suggest that ketoconazole may increase the bioavailability of Progesterone. The clinical relevance of the in vitro findings is unknown. Metabolism of Progesterone Capsules by liver was accelerated by hepatic inducers (e.g. barbiturate, antiepileptics, rifampicin).
Lab tests interaction: The following laboratory results may be modified by the use of Progesterone: levels of gonadotropins, plasma Progesterone and urinary pregnanediol.
