Vabon Dosage/Direction for Use

VABON is administered orally. For the treatment of endometriosis and fibrocystic breast disease, administration of the drug should be initiated during menstruation.
Endometriosis: For the palliative treatment of endometriosis in patients with moderate to severe disease or in patients who are infertile because of endometriosis, the usual initial dosage of VABON is 800 mg daily given in 2 divided doses. Amenorrhea and a rapid improvement in painful symptoms are best achieved at this dosage. Subsequent dosage may be gradually reduced, depending on the patient's therapeutic response, to a level sufficient to maintain amenorrhea. For the treatment of endometriosis in patients with mild disease, the usual initial dosage is 200 - 400 mg daily given in 2 divided doses. Subsequent dosage should be adjusted according to the patient's tolerance and therapeutic response.
Fibrocystic Breast Disease: For the symptomatic management of fibrocystic breast disease, the usual dosage of VABON is 100 - 400 mg daily given in 2 divided doses. Dosage should be individualized according to severity of the disease and the patient's response to treatment. Since ovulation may not be suppressed when VABON is administered at this dosage, an effective nonhormonal method of contraception is recommended during therapy with the drug.
Hereditary Angioedema: For the prophylactic treatment of hereditary angioedema, the usual initial dosage of VABON is 200 mg 2 or 3 times daily. After an initial response is obtained, subsequent maintenance dosage should be determined by decreasing the dosage by 50% or less at intervals of 1 - 3 months or longer, depending on the frequency of attacks prior to initiation of VABON therapy. If an attack occurs during treatment with the drug, dosage may be increased by up to 200 mg daily. Dosage requirements for continuous prophylaxis should be individualized according to the patient's response to treatment.
Menorrhagia: Adults, 200 mg daily for 12 weeks. In some cases the dosage may be increased to 400 mg daily or as directed by the physicians.
Primary Constitutional Precocious Puberty: Children, 100 - 200 mg daily according to the child's age and weight.