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During pharmacokinetic studies, no interactions with alcohol, digoxin, metformin, nifedipine, oral contraceptives, phenytoin, statins or warfarin have been observed.
Decreases in the absorption of vitamin D, E and β-carotene have been observed when co-administered with Xenical. If a multivitamin supplement is recommended, it should be taken at least 2 hrs after the administration of Xenical or at bedtime.
A reduction in cyclosporin plasma levels has been observed when Xenical is co-administered. Therefore, it is recommended to monitor more frequently than usual the cyclosporin plasma levels when Xenical is co-administered. (See Precautions.)
