Overdose of Xenical has not been reported. Single doses of 800 mg Xenical and multiple doses of up to 400 mg thrice daily for 15 days have been studied in normal weight and obese subjects without significant adverse findings. In addition, doses of 240 mg thrice daily have been administered to obese patients for 6 months without significant increase of adverse findings. Should a significant overdose of Xenical occur, it is recommended that the patient be observed for 24 hrs. Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible.
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