Chemotherapy- & RT-induced nausea & vomiting Adult 8-32 mg daily. Emetogenic chemotherapy & RT: 8 mg by slow IV inj immediately before treatment or orally 1-2 hr before treatment, followed by 8 mg orally every 12 hr for up to 5 days after a course of treatment to protect against delayed emesis. Highly emetogenic chemotherapy: Single dose of 8 mg by slow IV inj immediately before chemotherapy; or 8 mg by slow IV inj immediately before chemotherapy, followed by 2 further IV doses of 8 mg 2-4 hr apart, or by continuous IV infusion of 1 mg/hr for 24 hr; or single dose of 32 mg diluted in 50-100 mL of saline or other compatible fluids & infused over not <15 min immediately before chemotherapy. Continue w/ 8 mg orally bid for up to 5 days after a course of treatment to protect against delayed emesis after 1st 24 hr.
Childn 5 mg/m
2 IV immediately before chemotherapy, followed by 4 mg orally bid for up to 5 days after a course of treatment.
Post-op nausea & vomiting Adult Prevention: 4 mg IM or slow IV inj at induction of anaesth or single dose of 16 mg orally 1 hr prior to anaesth. Treatment: Single dose of 4 mg IM or slow IV inj.
Patient w/ hepatic impairment Max total daily dose: 8 mg.
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