Ondansetron should be used on scheduled basis, not on an "as needed" (PRN) basis, since data supports the use of this drug in the prevention of nausea and vomiting and not in the rescue of nausea and vomiting. Ondansetron should only be used in the first 24-48 hours of receiving chemotherapy. Data does not support any increased efficacy of ondansetron in delayed nausea and vomiting. Does not stimulate gastric or intestinal peristalsis; may mask progressive ileus and/or gastric distension.
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