Sign Out
Symptoms and signs: Aciclovir has been reported following administration inappropriately high doses and in patients with fluid and electrolyte imbalance, resulting in elevations in BUN and serum creatinine concentration and subsequent renal failure. Other adverse effects reported with aciclovir overdosage include agitation, coma, lethargy, and seizures. At renal concentration exceeding 2.5 mg/ml, aciclovir crystals may precipitate in the renal tubules, possibly causing renal dysfunction and eventual renal failure and anuria.
Treatment: Use of hemodialysis should be considered until renal function is restored. A 6-hour period of hemodialysis may result in a 60% decrease in plasma aciclovir concentrations. Patients should be observed closely for signs of toxicity.
