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Pregnancy: There are no adequate and controlled studies to date using aciclovir in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
Aciclovir is pregnancy category B. Aciclovir has been shown to cross the human placenta. Results from a pregnancy registry, established in 1984 and closed in 1999, did not find an increase in the number of birth defects with exposure to aciclovir when compared to those expected in the general population.
Lactation: Limited data indicate that aciclovir is distributed into milk, generally in concentration greater than concurrent maternal plasma concentrations, and can be absorbed by nursing infants. Aciclovir should be administered to nursing women with caution and only when indicated.
