Zinvel Adverse Reactions

Side effects include nausea, constipation, fatigue, confusion, hallucination, anemia, leucopenia, thrombocytopenia, muscle pain, vomiting, weakness, anorexia, fever, dyspnea, eye irritation, hypocalcemia, headache, diarrhea, bone pain and hypophosphatemia.
Administration is mostly associated with fever. Occasionally, patients experience a flu-like syndrome consisting of fever, chills, bone pain and/or arthralgia and myalgia.
Gastrointestinal reactions eg, nausea/vomiting and anorexia, have been reported following administration. Injection site reactions eg, erythema, redness or swelling were observed infrequently and resolved in most cases without treatment within 24-48 hrs.
Azotemia has been reported during therapy with zoledronic acid; serum creatinine should be monitored. Electrolyte imbalances may occur during treatment with zoledronic acid.
Hypocalcemia, hypomagnesemia and hypophosphatemia have been reported. Monitor serum calcium, phosphate and magnesium during therapy; short-term supplementation of these electrolytes may be necessary.